Non-canonical functions of the RB protein in cancer
Cet article passe en revue les travaux récents sur les mécanismes par lesquels, au-delà de la régulation des facteurs de transcription E2F, la protéine du rétinoblastome exerce une fonction de suppresseur de tumeur
The canonical model of RB-mediated tumour suppression developed over the past 30 years is based on the regulation of E2F transcription factors to restrict cell cycle progression. Several additional functions have been proposed for RB, on the basis of which a non-canonical RB pathway can be described. Mechanistically, the non-canonical RB pathway promotes histone modification and regulates chromosome structure in a manner distinct from cell cycle regulation. These functions have implications for chemotherapy response and resistance to targeted anticancer agents. This Opinion offers a framework to guide future studies of RB in basic and clinical research.