Who does not benefit from whole-breast radiotherapy and how to find them?
Menée à l'aide des données d'un essai randomisé multicentrique de phase III portant sur 589 patientes atteintes d'un cancer du sein de stade précoce, cette étude analyse, après 30 ans, l'efficacité d'une chirurgie conservatrice du sein avec ou sans radiothérapie
In The Lancet Oncology, Linda J Williams and colleagues present data from the 30-year update of the Scottish Breast Conservation Trial (SCT) comparing radiotherapy versus no radiotherapy after breast-conserving surgery in women with operable early breast cancer. 1 Briefly, local control (measured as ipsilateral breast tumour recurrence) was significantly better with radiotherapy versus without radiotherapy; however, this effect was only apparent within the first 10 years of follow-up, and there was no further benefit in the 20 subsequent years (hazard ratio [HR] 0·98 [95% CI 0·54–1·79]). Importantly, overall survival was not affected by the addition of radiotherapy to appropriate systemic treatment (HR 1·08 [95% CI 0·89–1·30], log-rank p=0·43).
The Lancet Oncology 2023