Human cancers express mutator phenotypes: origin, consequences and targeting
Cet article passe en revue les travaux récents venant à l’appui du concept de phénotype mutateur exprimé par les cellules cancéreuses
Recent data on DNA sequencing of human tumours have established that cancer cells contain thousands of mutations. These data support the concept that cancer cells express a mutator phenotype. This Perspective considers the evidence supporting the mutator phenotype hypothesis, the origin and consequences of a mutator phenotype, the implications for personalized medicine and the feasibility of ablating tumours by error catastrophe.