Benefits beyond measure: herd effects of HPV vaccines
Menée à partir de données de registres suédois portant sur 857 168 femmes nées entre 1985 et 2000, cette étude évalue l'immunité collective via l'analyse de l’incidence des lésions cervicales de haut grade chez les femmes non vaccinées contre le papillomavirus humain
In the Lancet Public Health, Eva Meglic and colleagues report estimates of the herd effects of human papillomavirus (HPV) vaccination on incidence of cervical precancer based on population registry data from the Swedish HPV vaccination and cervical cancer screening programmes. HPV is the necessary cause of almost all cervical cancers. Primary prevention with prophylactic HPV vaccination for adolescent girls and secondary prevention using HPV-based cervical screening for women of screening age have the potential to dramatically reduce cervical cancer mortality. Herd protection refers to the indirect benefit of prophylactic HPV vaccines for unvaccinated individuals. Such indirect protection is achieved through eliminating viral transmission of vaccine types to vaccinated individuals, which in turn leads to lower population prevalence of these HPV types, thereby resulting in reduced prevalence and related outcomes in unvaccinated individuals.
The Lancet Public Health , commentaire en libre accès, 2026