How safe and effective is irradiating radiation-induced meningiomas? Single-center experience in primary and salvage gamma-knife radiosurgery, systematic review, and metanalysis of current evidence on the topic
Menée à partir des données italiennes 2003-2024 portant sur 13 patients et à partir d'une revue systématique de la littérature publiée jusqu'en février 2024 (308 patients), cette méta-analyse évalue l'efficacité et la sécurité d'une radiochirurgie pour un méningiome radio-induit
This is a single-center experience and metanalysis of the safety and efficacy measures of Gamma-knife stereotactic radiosurgery (SRS-GK) for radiation-induced meningiomas (RIMs). This study comprised a single-center analysis of SRS-GK for RIMs at IRCCS San Raffaele Hospital, Milan, Italy, and a systematic literature review and meta-analysis to address the actuarial local control (LC), distant control (DC), progression-free survival (PFS), and toxicity. The original series comprised 13 patients harboring 30 RIMs. Partial response was observed in 26%, stability in 52%, and progression in 22%. The 5-year LC and DC rates were 71% and 67%. One patient developed radionecrosis, and an additional 2 presented edema. Metanalysis comprised 4 papers and data from the original series, comprising 146 patients and 308 RIMs. The 5-year LC was 84%, the DC 67%, and radionecrosis in 1.4%. SRS-GK has an efficacy profile falling between that observed for radiologically suspected sporadic meningiomas and confirmed higher-grade lesions.
Critical Reviews in Oncology/Hematology , résumé, 2024