Risk factors for preoperative frailty in older patients with gastric cancer: a systematic review and meta-analysis
A partir d'une revue systématique de la littérature (20 études, 51 717 patients), cette méta-analyse identifie des facteurs associés au risque de fragilité pré-opératoire chez des patients âgés atteints d'un cancer de l'estomac
Purpose: To summarize the available evidence on risk factors for preoperative frailty in older gastric cancer patients.
Methods: We comprehensively searched the CNKI, Wanfang, VIP, CBM, PubMed, Embase, The Cochrane Library, Web of Science, and CINAHL databases for preoperative articles on risk factors for frailty in older gastric cancer patients. The search was conducted from the time of construction of the library to January 27, 2024, with no language restrictions. The quality of the included studies was rated by the Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality tool.
Results: A total of 20 studies were included, including 16 cohort studies and 4 cross-sectional studies, with a total sample size of 51,717 individuals. The results of the meta-analysis showed that age, albumin, hemoglobin, cancer stage III-IV, Charlson Comorbidity Index score ≥ 3, Eastern Cooperative Oncology Group score > 2, American Society of Anesthesiologists score > 2, smoking, nutritional risk, high school degree or above, and sleep disorders are the main influencing factors for the occurrence of preoperative frailty in older gastric cancer patients. Among them, high school degree or above was a protective factor.
Conclusions: Our study provides valid evidence of risk factors for preoperative frailty in older patients with gastric cancer and informs clinical healthcare professionals to make targeted interventions.
Supportive Care in Cancer , résumé, 2024