Tumor microenvironment contribution to checkpoint blockade therapy. Lessons learned from Hodgkin lymphoma
Cet article analyse, pour plusieurs types de lymphome, l'influence du microenvironnement tumoral sur l'efficacité des inhibiteurs de point de contrôle immunitaire
Classic Hodgkin lymphoma (cHL) is characterized by a tumor microenvironment (TME) containing inflammatory/immune cells. Follicular lymphoma, mediastinal grey zone lymphoma and diffuse large B-cell lymphomas, may show a TME containing inflammatory/immune cells, but the TMEs are quite different. In these B-cell lymphomas and cHL, PD-1/PD-L1 blockade drugs differ in their effectiveness in patients with refractory/relapsed disease. Research should still explore innovative assays that could reveal which molecules are influencing the sensitivity or the resistance to therapy in an individual patient.
Blood , résumé, 2022