Aspirin-mediated prevention of colorectal adenomas recurrence is affected by blood biochemistry and nutritional intake
Menée à partir des données 2007-2009 d'un essai randomisé portant sur 231 hommes et 59 femmes, cette étude analyse l'association entre les caractéristiques des patients (âge, indice de masse corporelle, consommation d'alcool) et les facteurs sanguins (biochimie sanguine et nutriments) et l'effet chimiopréventif de l'aspirine en présence d'adénomes colorectaux
Aspirin has been shown to prevent the onset of colorectal adenoma and cancer. This study aimed to identify patient characteristics and blood chemistry factors related to the effect of aspirin. A total of 231 men and 59 women who participated in our previous randomized clinical study in 2007-2009 using aspirin or placebo (J-CAPP study) were analyzed. Interaction of aspirin with age at entry, body mass index (BMI), alcohol intake, blood biochemistry, and nutrients calculated from a semi-quantitative food frequency questionnaire were analyzed based on the presence of adenomas two years later. Our study showed that suppression of adenoma by aspirin was not affected by age or BMI. Among men, significant suppression of adenoma by aspirin was seen with triglyceride (TG) <167mg/dL (p=0.02), total cholesterol ≥220mg/dL (p=0.01), high-density lipoprotein (HDL) ≥60mg/dL (p<0.01), and low-density lipoprotein (LDL) ≥140mg/dL (p=0.01), AST <30IU/L (p=0.01), ALP <30IU/L (p=0.04), and γ-GTP <60 IU/L (p=0.04). Additionally, the interaction was significant with TG ≥/<167mg/dL (p=0.02), total cholesterol ≥/<220mg/dL (p=0.03), HDL ≥/<60mg/dL (p=0.02), LDL ≥/<140mg/dL (p=0.03), and AST ≥/<30IU/L (p=0.01). Daily nutrient intake associated with aspirin was <2000mg sodium (p=0.06) and ≥850µg retinol equivalent (p=0.05) among men, indicating a marginal effect on adenoma suppression. No significant differences were detected among women due to the small sample size. In conclusion, lipid metabolism and liver function were correlated with the suppressive effect of aspirin on the recurrence of colorectal adenoma.