Biological chemotaxis-guided self-thermophoretic nanoplatform augments colorectal cancer therapy through autonomous mucus penetration
Menée in vitro et à l'aide d'un modèle murin de cancer colorectal, cette étude met en évidence l'intérêt d'un nanodispositif, constitué de nanoparticules de silice, d'une couche de platine, de molécules de polyéthylène-gycol couplées à du glucose et d'une membrane de Staphylococcus aureus, pour améliorer le transport d'anticancéreux oraux vers les sites tumoraux et favoriser, à l'aide d'un laser en proche infrarouge, leur pénétration du mucus intestinal par thermophorèse
Oral drug delivery systems have great potential to treat colorectal cancer (CRC). However, the drug delivery efficiency is restricted by limited CRC-related intestine positioning and dense mucus barrier. Here, we present a biological chemotaxis-guided self-thermophoretic nanoplatform that facilitates precise intestinal positioning and autonomous mucus penetration. The nanoplatform introduces asymmetric platinum-sprayed mesoporous silica to achieve autonomous movement in intestinal mucus. Furthermore, inspired by the intense interaction between pathogenic microbes and CRC, the nanoplatform is camouflaged by Staphylococcus aureus membrane to precisely anchor in CRC-related intestine. Owing to 4.3-fold higher biological chemotactic anchoring of CRC-related intestine and 14.6-fold higher autonomous mucus penetration performance, the nanoplatform vastly improves the oral bioavailability of cisplatin, leading to a tumor inhibition rate of 99.1% on orthotopic CRC–bearing mice. Together, the exquisitely designed nanoplatform to overcome multiple physiological barriers provides a new horizon for the development of oral drug delivery systems.
Science Advances 2022