Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T-cell responses
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
How immune dysregulation affects recovery from COVID-19 infection in patients with cancer remains unclear. We analyzed cellular and humoral immune responses in 103 patients with prior COVID-19 infection, over 20% of whom had delayed viral clearance. Delayed clearance was associated with loss of antibodies to nucleocapsid and spike proteins with a compensatory increase in functional T-cell responses. High-dimensional analysis of peripheral blood samples demonstrated increased CD8+ effector T-cell differentiation and a broad but poorly converged COVID-specific TCR repertoire in patients with prolonged disease. Conversely, patients with a CD4+ dominant immunophenotype had a lower incidence of prolonged disease and exhibited a deep and highly selected COVID-associated TCR repertoire, consistent with effective viral clearance and development of T-cell memory. These results highlight the importance of B-cells and CD4+ T-cells in promoting durable SARS-CoV-2 clearance and the significance of coordinated cellular and humoral immunity for long-term disease control.
Cancer Cell , résumé, 2021