Persistence of long-term COVID-19 sequelae in patients with cancer: an analysis from the OnCovid registry
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Introduction : A significant proportion of patients with cancer who recover from COVID-19 may experience COVID-19 sequelae in the early post-infection phase, which negatively affect the continuity of care and oncological outcome. The long-term prevalence and clinical impact of post-COVID-19 syndrome in patients with cancer are largely unknown.
Methods : In this study, we describe the time course of COVID-19 sequelae in patients with non-advanced cancers enrolled into the OnCovid registry.
Results : Overall, 186 patients were included, with a median observation period of 9.9 months (95%CI:8,8-11.3) post COVID-19 resolution. After a median interval of 2.3 months post-COVID-19 (interquartile range: 1.4-3.7), 31 patients (16.6%) reported >1 sequelae, including respiratory complications (14, 7.6%), fatigue (13, 7.1%), neuro-cognitive sequelae (7, 3.8%). The vast majority of the patients were not vaccinated prior to COVID-19. COVID-19-related sequelae persisted in 9.8% and 8% of patients 6 and 12 months after COVID-19 resolution. Persistence of sequelae at first oncological follow-up was associated with history of complicated COVID-19 (45.2% vs 24.8%, p=0.0223), irrespective of oncological features at COVID-19 diagnosis.
Conclusion : This study confirms for the first time that, in a largely unvaccinated population, post-COVID-19 syndrome can affect a significant proportion of patients with non-advanced cancer who recovered from the acute illness. COVID-19 sequelae may persist up to 12 months in some patients, highlighting the need for dedicated prevention and supportive strategies.
European Journal of Cancer , résumé, 2021