Room to Grow: The Need for Cancer Site-Specific Research into Biomarkers of Aging and Immunity in People with HIV
Menée à partir de données portant sur 83 893 patients adultes infectés par le VIH (âge médian : 43 ans), cette étude évalue l'association entre le rapport lymphocytes CD4+ / lymphocytes CD8+ et le risque de développer un cancer
HIV and cancer have been inextricably linked since the beginning of the HIV epidemic in the United States. The unexpected clustering of Kaposi sarcoma (KS) diagnoses was one of the first pieces of evidence that a new epidemic was emerging.1 Immunosuppression resulting from HIV-mediated depletion of host CD4+ T-cells impairs the ability of people with HIV (PWH) to control infections, resulting in higher rates of virus-associated cancers such as KS.2 The current cancer profile of PWH is also influenced by the fact that antiretroviral therapy (ART) has improved survival and dramatically changed the age structure of the HIV population, with more than one-fifth of PWH projected to be >65 years by 2030.3 This longevity has translated into an increasing cancer burden that now includes age-related tumors not linked to infection. One of the important questions that follows from this changing epidemiology is whether biomarkers can be identified to predict which PWH will develop cancer.
Journal of the National Cancer Institute , éditorial en libre accès, 2021