One-off low-dose CT lung cancer screening in China: an appropriate strategy?
Menée en Chine à partir de données portant sur 1 016 740 personnes (âge : 70 à 76 ans ; durée médiane de suivi : 3,6 ans), cette étude évalue la performance d'une unique tomographie numérique à faible dose de rayonnements ionisants pour réduire l'incidence du cancer du poumon et la mortalité liée à la maladie ou toutes causes confondues
Lung cancer is devastating, with a 5-year survival rate of about 10%. High smoking prevalence in the past means that millions of people are at high risk of developing lung cancer. Two large-scale randomised controlled trials (RCTs) have shown that screening with high-quality, low-dose CT (LDCT) can detect lung cancer substantially earlier than when being diagnosed symptomatically, and thereby reduce mortality from the disease by 8–24% (point estimates of trials) in men and by 26–61% in women.
The Lancet Respiratory Medicine , commentaire, 2021