Association between Hepatitis B and E virus infection and hepatocellular carcinoma risk
Menée à partir d'échantillons sanguins prélevés sur 474 patients atteints d'un carcinome hépatocellulaire et 586 témoins, cette étude analyse l'association entre une infection par le virus de l'hépatite E, une infection conjointe par le virus de l'hépatite B et le risque de cancer du foie, en fonction du sexe
The role of hepatitis E virus (HEV) in developing hepatocellular carcinoma (HCC) is unclear. This study aimed to investigate the role of HE infection in HCC development and the effect of hepatitis B virus (HBV) and HEV co-infection on HCC risk. A hospital-based case-control study was conducted. A total of 474 eligible HCC cases and 586 control patients were successfully recruited. The fasting venous blood was collected from the patients at the first visited to hospital and HBV infection and HEV infection were examined within five days. Crude and adjusted odd ratios (OR) with 95% confidence interval (95% CI) were estimated by using logistic regression model. HBV infection (OR: 63.10, 95% CI: 42.02 - 97.26) rather than HEV infection (OR: 1.08, 95% CI: 0.721-1.65) was associated with an increased risk of HCC after adjustment for confounders. The association between HBV infection and HCC risk was more remarkable in male (OR: 72.61, 95% CI:45.10 – 121.38) than in female (OR: 61.89, 95% CI: 25.74 – 169.26). In comparison with patients who infected with neither HEV nor HBV, those who infected with only HBV (OR: 69.62, 95% CI: 40.90 - 123.52) and who co-infected with HEV and HBV (OR: 67.48, 95% CI:37.23 - 128.19) were significantly associated with an increased risk after adjustment for potential confounders. The results showed that HBV infection rather than HEV infection was associated with an increased risk of HCC, and the HEV infection may alleviate the promoting impact of HBV on HCC development.