The current paradigm and challenges ahead for the dormancy of disseminated tumor cells
Cet article passe en revue les connaissances récentes sur la dormance des cellules tumorales déssiminées et analyse la façon dont ces découvertes peuvent conduire à de nouvelles stratégies pour surveiller et cibler ce type de cellules cancéreuses
Disseminated tumor cells (DTCs) are known to enter a state of dormancy that is achieved via growth arrest of DTCs and/or a form of population equilibrium state, strongly influenced by the organ microenvironment. During this time, expansion of residual disseminated cancer is paused and DTCs survive to fuel relapse, sometimes decades later. This notion has opened a new window of opportunity for intervening and preventing relapse. Here we review recent data that have further augmented the understanding of cancer dormancy and discuss how this is leading to new strategies for monitoring and targeting dormant cancer.
Nature Cancer , résumé, 2020