• Lutte contre les cancers

  • Observation

  • Colon-rectum

Sessile serrated polyps and colorectal cancer mortality

Menée en Suède sur la période 1993-2016 à partir de données portant sur 178 377 patients atteints d’un polype colorectal (âge moyen lors du diagnostic : 58,6 ans) et sur 864 831 témoins, cette étude de cohorte analyse le risque de cancer colorectal après une polypectomie ainsi que la mortalité spécifique en fonction du sous-type histologique du polype (durée médiane de suivi : 6,6 ans ; 4 278 cas de cancer, 1 269 décès par cancer)

Beliefs about how colorectal cancer develops have evolved over time. Remaining sources of uncertainty include whether all cases develop from premalignant polyps, which polyps confer the highest risk, and what risk persists after polyp removal. Although polyp detection and removal can substantially reduce colorectal cancer mortality, this approach is not 100% effective at preventing death. Polyps come in different shapes and sizes and with different microscopic features, and exactly how some characteristics affect patient outcomes is uncertain. An area of particular uncertainty is the risk in patients with sessile serrated polyps, a more recently recognised precursor for colorectal cancer. Addressing these questions is increasingly urgent as efforts to prevent the disease intensify and more patients have polyps removed.

The Lancet Gastroenterology and Hepatology , commentaire, 2019

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