Risk factors for extrahepatic cholangiocarcinoma: a case–control study in China
Menée en Chine à partir de données portant sur 200 patients atteints d'un cholangiocarcinome extra-hépatique et sur 200 témoins, cette étude évalue les divers facteurs (tabagisme, consommation d'alcool, diabète, hépatite B, etc...) associés au risque de développer la maladie
To investigate risk factors for extrahepatic cholangiocarcinoma (ECC) in China. A total of 200 ECC cases and 200 matched control were included in the study. The presence of cigarette smoking, alcohol drinking, choledocholithiasis, primary sclerosing cholangitis, liver fluke infection (Clonorchis sinensis), diabetes mellitus, was investigated through clinical records. Blood from all cases was tested for hepatitis B surface antigen. Odds ratios (OR) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. Compared with controls, ECC patients had a higher prevalence of cigarette smoking (61.0 vs. 47.0%, P=0.007), alcohol drinking (17.5 vs. 3.5%, P<0.000), and choledocholithiasis (6.0 vs. 1.0%, P=0.011). By multivariate analysis, the significant risk factors for the development of ECC were current smoking (OR=1.90, 95% CI=1.08–3.34), heavy alcohol drinking (OR=2.08, 95% CI=1.39–3.13), and choledocholithiasis (OR=6.68, 95% CI=1.48–30.27). The prevalence of hepatitis B virus infection, diabetes mellitus were not significantly different between cases and controls. These findings suggest that smoking, alcohol drinking, and choledocholithiasis are positive risk factors for the development of ECC in China. Correspondence to Pin Lv, PhD, Department of Hepatobiliary Surgery, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410000, China Tel: +86 132 986 8285; fax: +86 731 8392 8036; e-mail: lvpincs@163.com Received November 23, 2017 Accepted August 5, 2018 Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.