Towards improving accuracy, effectiveness, and efficiency in breast cancer screening
Mené en Suède auprès de 14 848 femmes ayant participé à un programme de dépistage du cancer du sein (âge : 40 à 74 ans), cet essai compare, du point de vue de la sensibilité, de la spécificité et du taux de cancers détectés, la performance d'une tomosynthèse mammaire numérique en simple lecture et d'une mammographie numérique en double lecture
Mammography screening contributes to reductions in mortality and morbidity from breast cancer through earlier detection of lesions. The sensitivity and specificity of digital mammography is reduced in some conditions, particularly in women with dense fibroglandular breasts within which overlying structures can mask cancers or mimic lesions that don't exist. Digital breast tomosynthesis is a refinement of digital mammography in which multiple low-dose x-ray projection images are acquired over a range of angles about the breast and used to reconstruct a quasi-3D image set. By depicting the anatomy of the breast as a stack of slices, the decreased accuracy caused by overlapping densities is often mitigated. Several studies have shown improved sensitivity or specificity, or both, of digital breast tomosynthesis in screening compared with standard two-view digital mammography.
The Lancet Oncology , commentaire, 2017