A genetic variant located in miR-146b promoter region is associated with prognosis of gastric cancer
Menée en Chine à partir de données portant sur 940 patients atteints d'un cancer gastrique, cette étude met en évidence une association entre un variant génétique situé dans la région du promoteur du gène codant pour le microARN miR-146b et la survie des patients
Background : Single nucleotide polymorphisms (SNPs) in the promoter region of microRNAs (miRNAs) have been reported to be associated with cancer prognosis. Our previous study found that miR-146b had a strong correlation with the stage classification of gastric cancer and contributed to tumor progression. The present study was aimed at investigating whether an SNP located in the promoter region of miR-146b could affect the survival rate of gastric cancer.
Methods : Using bioinformatics tools, we identified one SNP (rs1536309) that is located in the miR-146b promoter. We genotyped this SNP site to assess its association with gastric cancer prognosis in 940 cases.
Results : We found that the dominant model of miR-146b rs1536309 was associated with a higher survival rate of gastric cancer. The association remained significant in the subgroup analysis by age (≤60), sex (male), tumor size (≤5cm), histological type (diffuse), lymph node metastasis (N0), distant metastasis (M0) and TNM stage (I/II).
Conclusions : Our results suggested that the miR-146b rs1536309 polymorphism may be a potential biomarker for the prognosis of gastric cancer.
Impact :This is the first evidence showing that patients carrying the miR-146b-5p rs1536309 CC/CT genotypes exhibited better survival than those carrying the TT genotype, suggesting the protective effect of the C allele in the prognosis of gastric cancer.
Cancer Epidemiology Biomarkers & Prevention , résumé, 2017