Genome-wide association studies in glioma
A partir des données des études d'association sur le génome entier portant sur des patients atteints d'un gliome, notamment celle d'une étude récente comprenant 12 496 patients et 18 190 témoins, cette étude passe en revue les 27 polymorphismes à simple nucléotide de gènes impliqués dans l'étiologie de la maladie
Since the first reports in 2009, genome-wide association studies (GWAS) have been successful in identifying germline variants associated with glioma susceptibility. In this review we describe a chronological history of glioma GWAS, culminating in the most recent study comprising 12,496 cases and 18,190 controls. We additionally summarise associations at the 27 glioma risk SNPs that have been reported so far. Future efforts are likely to be principally focused on assessing association of germline risk SNPs with particular molecular subgroups of glioma, as well as investigating the functional basis of the risk loci in tumour formation. These ongoing studies will be important to maximise the impact of research into glioma susceptibility, both in terms of insight into tumour aetiology as well as opportunities for clinical translation.