Bone voyage—Osteoblasts remotely control tumors
Menée à l'aide de modèles murins d'adénocarcinome du poumon, cette étude met en évidence des mécanismes par lesquels, même en l'absence de métastases osseuses, les cellules de la tumeur primitive activent à distance des ostéoblastes, ce qui induit la production de neutrophiles infiltrant la tumeur et favorise sa croissance
Cancer is a systemic disease. Tumor growth and malignant progression rely not only on the intrinsic aberrant genetic and epigenetic makeup of tumor cells but also on the tumor-induced systemic factors that affect cells in the primary tumor as well as distant microenvironments (1). Notably, bone marrow-derived cells (BMDCs) have been shown to contribute to primary tumor progression by promoting hallmark processes such as inflammation, immunosuppression, vasculogenesis, and extracellular matrix remodeling. BMDCs are also involved in establishing tumor-permissive microenvironments that form before the arrival of disseminated tumor cells at future metastatic sites (known as premetastatic niches) and promote metastatic outgrowth (2–5). In addition to the direct effects of tumor-secreted factors on BMDC recruitment to tumors, on page eaal5081 of this issue Engblom et al. (6) report that osteoblasts, which reside in the bone, can be remotely activated by secreted factors from lung adenocarcinoma, which in turn mobilize a specific subset of BMDCs—neutrophils—to foster tumor growth.
Science , commentaire, 2016