Does Q fever contribute to pathogenesis of non-Hodgkin lymphoma?
Menée aux Pays-Bas à partir de données portant sur 48 760 patients atteints d'un lymphome non hodgkinien, cette étude rétrospective évalue l'association entre une exposition à une épidémie de fièvre Q par inhalation de Coxiella burnetii et le risque de développer la maladie
A typical question patients with non-Hodgkin lymphoma ask their physicians is “what caused this cancer?” In most cases, the answer remains elusive. Some bacterial and viral infections—eg, Helicobacter pylori, Chlamydia psittaci, Epstein-Barr virus, and human lymphotropic virus type I—are associated with development of some lymphomas.1–3 The association of Q fever with lymphoma, however, is less clear. Coxiella burnetii, which causes Q fever, is an intracellular bacterium that typically resides in macrophages.
The Lancet Haematology , 2018