Esophageal resection for cancer after neoadjuvant chemoradiation: To wait or not to wait?
Menée à partir de données portant sur 234 patients atteints d'un cancer de l'œsophage traité entre 2000 et 2015 (âge médian : 64 ans), cette étude évalue l'effet du délai entre chimioradiothérapie néoadjuvante et traitement chirurgical sur le taux de réponse pathologique complète et la survie
The ideal time interval for esophagectomy after neoadjuvant chemoradiotherapy (CRT) for patients with esophageal cancer is unknown, but in most centers, the operation is usually performed 4 to 8 weeks after CRT when the patient has fully recovered. A similar time interval between CRT and operation has traditionally been accepted for patients with rectal cancer; however, recent studies1,2 have suggested that a longer wait may increase the rate of pathologic complete responses (pCRs) and may improve survival.
JAMA Surgery , commentaire, 2015