Oncogenic PTEN functions and models in T-cell malignancies
Cet article passe en revue les études précliniques récentes mettant en évidence le rôle joué par la perte d'expression de PTEN dans les leucémies lymphoblastiques aiguës T et les lymphomes T
PTEN is a protein phosphatase that is crucial to prevent the malignant transformation of T-cells. Although a numerous mechanisms regulate its expression and function, they are often altered in T-cell acute lymphoblastic leukaemias and T-cell lymphomas. As such, PTEN inactivation frequently occurs in these malignancies, where it can be associated with chemotherapy resistance and poor prognosis. Different Pten knockout models recapitulated the development of T-cell leukaemia/lymphoma, demonstrating that PTEN loss is at the center of a complex oncogenic network that sustains and drives tumorigenesis via the activation of multiple signalling pathways. These aspects and their therapeutic implications are discussed in this review.
Oncogene , résumé, 2014