Evolutionary Precision Medicine: A Role for Repeat Epidermal Growth Factor Receptor Analysis in ALK-Rearranged Lung Adenocarcinoma?
A partir d'échantillons tumoraux prélevés sur 629 patients atteints d'un adénocarcinome du poumon, cette étude met en évidence une hétérogénéité intratumorale des réarrangements du gène ALK et/ou des mutations du gène EGFR
Genetic alterations in the anaplastic lymphoma kinase gene (ALK) that result in fusion proteins are detected in approximately 1% to 2% of unselected non–small-cell lung cancer (NSCLC) tumors. In NSCLC, the most common fusion partner is EML4, but several other ALK fusion partners that result in a constitutively active kinase domain with potent transforming capability in vitro have been described...
Journal of Clinical Oncology , éditorial en libre accès, 2015