• Etiologie

  • Facteurs exogènes : Tabac

  • Col de l'utérus

Effects of active, passive, and combined smoking on cervical cancer mortality: a nationwide proportional mortality study in Chinese urban women

Menée en Chine à partir de données portant sur le comportement tabagique de 1 865 femmes décédées d'un cancer du col de l'utérus (âge supérieur à 35 ans) et sur 48 781 femmes décédées de causes non liées au tabagisme, cette étude évalue l'effet du tabagisme actif et/ou du tabagisme passif sur le risque de décès par cancer du col de l'utérus

Purpose : To determine whether smoking, in any form, is a risk factor in the development of cervical cancer (CC) among urban Chinese women. Methods : We ascertained retrospectively the smoking habits of 1,865 women (aged 35+) who had died from CC (cases) and 48,781 who had died from causes unrelated to smoking (controls) in 24 cities using data from a large national survey of smoking and mortality in 1989–1991. We assessed the risk of smoking on CC mortality with and without considering passive smoke exposure from a spouse using a proportional mortality study design. Results : Overall, there was a 51.0 % excess risk of death from CC among smokers. When the spouse’s exposure was further considered, the RR (95 % CI) for exposed versus unexposed women was 1.28 (1.04–1.57) for passive smokers, 1.49 (1.02–2.20) for active smokers, and 1.69 (1.27–2.26) for women with both exposures (all p < 0.001). Significant dose–response associations were observed between smoking and CC for all categories of exposure. For example, individuals with both smoking exposure had the highest risk of CC mortality with moderate [RR = 1.67 (1.18–2.38)] and high [RR = 1.88 (1.04–3.41)] daily cigarette consumption, and they also had the highest risk with ≤15 years exposure [RR = 1.73 (1.19–2.52)] and >15 years exposure [RR = 1.95 (1.15–3.32)], compared with the active and passive groups (p for trend <0.001). Conclusions : Younger trend of CC death and the rapid increase in smoking among young women may have a profound impact on future incidence of CC. Our findings emphasize the need for preventive efforts among both women and men in China.

Cancer Causes & Control 2015

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