Translocation t(2;11) in CLL cells results in CXCR4/MAML2 fusion oncogene
Menée sur un patient atteint d'une leucémie lymphocytaire chronique, cette étude identifie un nouveau gène de fusion associant une portion du gène CXCR4 au gène MAML2
Recent investigations of chromosomal aberrations in CLL led to a better understanding of the molecular causes of chronic lymphocytic leukemia. Here we report a rearrangement between MAML2 (mastermind like protein 2) and CXCR4 (specific receptor for CXC chemokine stromal cell-derived factor-1) in CLL cells of a patient with a t(2;11)(q22.1;q21) chromosomal translocation. The rearrangement between MAML2 and CXCR4, created by a t(2;11)(q22.1;q21) translocation, results in a new fusion gene in which a portion of CXCR4 is linked to the MAML2 gene. This fusion gene encodes for CXCR4/MAML2 protein chimera in which the N-terminal basic domain of MAML2 is replaced by the N-terminal domain of CXCR4.Submitted February 5, 2014.Accepted May 7, 2014.Copyright © 2014 American Society of Hematology
Blood 2014