Evolving Treatment Paradigms for Primary Mediastinal Diffuse Large B-Cell Lymphoma
Menée sur 115 patients atteints d'un lymphome primitif du médiastin à grandes cellules B traité par chimioimmunothérapie à base d'anthracycline et de rituximab, cette étude internationale met en évidence l'intérêt d'une tomographie numérique par émission de positrons à base de fluorodésoxyglucose (18F) pour prédire la survie
Primary mediastinal diffuse large B-cell lymphoma (PMBL) was first described in the1980s as a distinct clinicopathologic entity. In the last three decades we have realized significant advances in our understanding of its disease biology while developing therapeutic regimens associated with high cure rates. PMBL is defined by a rapidly growing dominant mediastinal mass, frequently accompanied by local invasiveness and superior vena cava syndrome ; involvement outside of the thorax at initial presentation is infrequent and virtually never includes bone marrow...
Journal of Clinical Oncology , éditorial en libre accès, 2014