Next-Generation Genomic Profiling of Hepatocellular Adenomas: A New Era of Individualized Patient Care
Menée à partir de 250 échantillons tumoraux prélevés sur 195 patients atteints d'un adénome hépatocellulaire, cette étude française identifie un ensemble d'anomalies génomiques impliquées dans la transformation maligne
Hepatocellular adenomas (HCAs) are clinically relevant benign liver lesions that commonly occur in women on hormonal contraceptives. In this issue of Cancer Cell, Pilati and colleagues present an integrative multi-?omics?-based analysis of HCA and identify recurrent genetic alterations associated with adenoma-carcinoma transition and new drugable targets.
Cancer Cell , commentaire, 2013