Nutritional Status As a Prognostic Indicator for Pediatric Malignancies
Menée sur une cohorte de 2 008 enfants traités pour une leucémie lymphoblastique à haut risque de récidive, cette étude évalue l'association entre la durée d'une insuffisance ou d'une surcharge pondérale extrême durant le traitement et la survie sans événement ou la toxicité thérapeutique
Although malnutrition is frequently cited as a poor prognostic indicator for pediatric oncology patients, nutritional status is infrequently evaluated as a component of clinical trials. Malnutrition has been used interchangeably with undernutrition or protein-energy malnutrition. It is now recognized that there is another end of the spectrum—that is, patients who are obese. The majority of pediatric oncology studies that have reported on an impact of nutritional status on outcomes have only evaluated patients at diagnosis. They did not report on the nutritional changes that occur during treatment and that may have an effect on outcomes. Donaldson et al and Mauer et al brought it to our attention that nutritional status should be considered by treating pediatric oncologists...
Journal of Clinical Oncology , éditorial en libre accès, 2014