The prevalence of colorectal adenomas in asymptomatic Korean men and women
Menée en Corée auprès de 19 372 participants âgés de 20 à 79 ans, cette étude transversale analyse l'évolution de la prévalence d'adénomes colorectaux en fonction de l'âge et du sexe, chez des individus ne présentant pas de symptômes
Background:Colorectal cancer incidence is rapidly rising in many Asian countries, with rates approaching those of Western countries. This study aimed to evaluate the prevalence and trends of colorectal adenomas by age, sex, and risk strata in asymptomatic in Koreans. Methods:Cross-sectional study of 19,372 consecutive participants aged 20-79 years undergoing screening colonoscopy at the Center for Health Promotion of the Samsung Medical Center in Korea from January 2006 to June 2009. Results:Among participants at average risk, those without a history of colorectal polyps or a family history of colorectal cancer, the prevalence of colorectal adenomas and advanced adenomas were 34.5 and 3.1%, respectively, in men and 20.0 and 1.6%, respectively, in women. The prevalence of adenomas increased with age in both men and women, with a more marked increase for advanced adenoma. Participants with a family history of colorectal cancer or with a history of colorectal polyps had significantly higher prevalence of adenomas compared to participants of average risk (36.9 vs. 26.9%; age- and sex-adjusted prevalence ratio [aPR] 1.16, 95% confidence interval [CI] 1.09, 1.22). The prevalence of adenomas increased annually in both men and women. Conclusions:In this large study of asymptomatic, the prevalence of colorectal adenomas among Koreans was comparable and possibly higher than previously reported in Western countries. Impact:Cost-effectiveness studies investigating the optimal age for starting colonoscopy screening and etiological studies to identify the reasons for the increasing trend in colorectal adenomas in Koreans are needed.