Circulating Tumor cells in Hodgkin's Lymphoma- A review of the spread of HL tumor cells or their putative precursors by lymphatic and hematogenous means, and their prognostic significance
Cet article passe en revue les travaux récents sur l'intérêt des cellules tumorales circulantes pour la prise en charge des patients atteints d'un lymphome hodgkinien classique
About 15% of patients diagnosed with classical Hodgkin's lymphoma (cHL) are considered, high risk with unfavorable prognosis. The biology of the disease bears a direct relationship to its, clinical course. However, some aspects of the disease are still being debated. Related topics include, origin of neoplastic cells as circulating precursor versus germinal center B cell, and disease metastasis, via hematogenous routes and the effect of HL circulation on relapse potential and further spread of the, disease. The terminally differentiated giant neoplastic Hodgkin Reed-Sternberg (HRS) cells (HRSC), have limited proliferation and lack mobility. Therefore, they are unable penetrate epithelium. Thus, the, clinical aggressiveness of HRSCs that disseminate via both lymphatic and hematogenous may be, determined by their molecular composition. This review discusses in detail the historical perspectives, on scientific and clinical evidences of precursors of circulating HL cells and the prognostic importance, of these circulating cells for predicting outcome.
Critical Reviews in Oncology/Hematology , résumé, 2012