A New Brew of MALT1 Inhibitors
Menées in vitro et in vivo, ces deux études mettent en évidence l'intérêt de cibler la paracaspase MALT1 pour le traitement d'une forme chimiorésistante du lymphome diffus à grandes cellules B
The activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL) is an aggressive lymphoma that is addicted to NF-ºB signaling through the CARD11-BCL10-MALT1 complex. In this issue of Cancer Cell, Nagel and colleagues and Fontan and colleagues describe MALT1 inhibitors suitable for clinical use that are selectively toxic to this malignancy.
Cancer cell , commentaire, 2011