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Menée sur un modèle murin, cette étude met en évidence un mécanisme par lequel, en amplifiant la transcription de certains gènes, le facteur c-Myc favorise la croissance des cellules tumorales
Myc is an enigma wrapped in a mystery. Attempts to identify Myc target genes, particularly in cancer, have been fraught with dead ends and context-specific functions. Lin et al. and Nie et al. address this conundrum by showing that Myc acts to amplify the output of existing transcriptionally active genes.
Cell , commentaire, 2011