Molecular Aspects of Vitamin D Anticancer Activity
Cet article passe en revue les études récentes concernant les mécanismes par lesquels le calcitriol peut inhiber la carcinogenèse et fait le point sur les niveaux sanguins de vitamine D associés à cette inhibition
Environment may influence the development and prevention of cancer. Calcitriol has been associated with calcium homeostasis regulation. Many epidemiological, biochemical, and genetic studies have shown non-classic effects of vitamin D, such as its involvement in the progression of different cancers. Although vitamin D induces cellular arrest, triggers apoptotic pathways, inhibits angiogenesis, and alters cellular adhesion, the precise mechanisms of its action are still not completely established. This article will present a revision about the molecular aspects proposed to be involved in the anticancer action of calcitriol. Adequate levels of vitamin D to prevent cancer development will also be discussed.
Cancer Investigation 2012