Statin use and risk of prostate cancer in the prospective Osteoporotic Fractures in Men (MrOS) Study
Menée aux Etas-Unis, cette étude de cohorte prospective incluant 5 069 participants analyse l'association entre l'utilisation de statines et le risque de cancer de la prostate
Background: Statins are a common medication for cholesterol control that may also have effects on cancer-related pathways. The evidence of an association between statins and prostate cancer risk remains ambiguous. Methods: We examined statin use in a prospective cohort of 5069 elderly US men and the risk of incident total, low/high stage, and low/high grade prostate cancer diagnosed between 2000-2008. We used multivariate logistic regression models to estimate relative risks and 95% confidence intervals, adjusting for demographic and lifestyle characteristics. Results: There was no evidence of an association between statin use and any of the prostate cancer endpoints (total, low/high stage, low/high grade prostate cancer), adjusting for age, study site, race, body mass index, marital status, family history of prostate cancer, number of comorbidities, physical activity, and smoking history. Conclusions: In this study of elderly US men, we observed a null association between statin use and risk of prostate cancer.