Risk factors for gallbladder cancer: A case-control study
Menée en Inde, cette étude (200 cas et 200 témoins) analyse divers facteurs de risque du cancer de la vésicule biliaire
Risk factors for gallbladder cancer (GBC) except gallstones are not well-known. The objective was to study risk factors for GBC. In a case-control study, 200 patients with GBC, 200 healthy controls and 200 gallstones patients as diseased controls were included prospectively. The risk factors studied were related to socio-economic profile, life-style, reproduction, diet and bile acids. On comparing GBC patients (mean age 51.7 years; 130 females) with healthy controls, risk factors were chemical exposure {OR: 7.0 (2.7-18.2); p<0.001)}, family history of gallstones {OR: 5.3 (1.5-18.9); p<0.01)}, tobacco {OR: 4.1 (1.8-9.7); p<0.001)}, fried foods {OR: 3.1 (1.7-5.6); p<0.001}, joint family {OR: 3.2 (1.7-6.2); p<0.001}, long interval between meals {OR: 1.4 (1.2-1.6); p<0.001} and residence in Gangetic belt {OR: 3.3 (1.8-6.2); p<0.001}. On comparing GBC cases with gallstone controls, risk factors were female gender {OR: 2.4 (1.3-4.3); p=0.004}, residence in Gangetic belt {OR: 2.3 (1.2-4.4); p=0.012}, fried foods {OR: 2.5 (1.4-4.4); p<0.001}, diabetes {OR: 2.7 (1.2-6.4); p=0.02)}, tobacco {OR 3.8 (1.7-8.1); p<0.001)}, and joint family {OR: 2.1 (1.2-3.4); p=0.004}. The ratio of secondary to primary bile acids was significantly higher in GBC cases than gallstone controls (20.8 vs. 0.44). Fried foods, tobacco, chemical exposure, family history of gallstones, residence in Gangetic belt, and secondary bile acids were significant risk factors for GBC. © 2012 Wiley Periodicals, Inc.