Pathogen-driven gastrointestinal cancers: Time for a change in treatment paradigm?
Cette étude passe en revue les associations entre une inflammation chronique, une colonisation bactérienne, une infection virale et le risque de cancer gastrointestinal
The regulation of cancerous tumor development is converged upon by multiple pathways and factors. Besides environmental factors, Pathogen-driven gastrointestinal cancers: Time for a change in treatment paradigm?cancer can be caused by chronic inflammation, which is generally induced by bacteria, viruses, and parasites. The role of these inducers in cancer development, cell differentiation and transformation, cell cycle deregulation, and in the expression of tumor-associated genes cannot be ignored. Although Helicobacter pylori activates many oncogenic pathways, particularly those in gastric and colorectal cancers, the role of viruses in tumor development is also significant. Viruses possess significant oncogenic potential to interfere with normal cell cycle control and genome stability, stimulating the growth of deregulated cells. An increasing amount of recent data also implies the association of GI cancers with bacterial colonization and viruses. This review focuses on host-cell interactions that facilitate primary mechanisms of tumorigenesis and provides new insights into novel GI cancer treatments.