A functional polymorphism of lymphotoxin-alpha (LTA) gene rs909253 is associated with gastric cancer risk in an Asian population
A partir d'une revue de la littérature (12 études), cette méta-analyse montre une association entre le polymorphisme fonctionnel rs909253 du gène de la lymphotoxine-alpha et le risque de cancer gastrique chez les personnes d'origine asiatique (2 074 cas et 3 690 témoins)
Background : The potentially functional polymorphism, rs909253 (+252 G>A), in the intron region of the LT-
α (TNF-β) gene has been implicated in the risk of gastric cancer (GC) in some individually published studies, but others have shown inconsistent and inconclusive results. Methods
:
We conducted a meta-analysis to assess the association between the lymphotoxin-α gene (LTA) + 252 (G>A) polymorphism and gastric cancer susceptibility. Results
:
We demonstrate that there were no significant associations in single-locus analysis between the polymorphism of LTA and gastric cancer risk in all subjects; however, when studies were stratified by ethnicity, these polymorphisms of LTA were found to be associated with a significant cancer risk in different genetic models in an Asian population (heterozygote [GA genotype] comparison: odds ratio [OR] = 1.29, 95% confidence interval [CI]: 1.01
–1.65, P = 0.038) in which the risk in the subjects was more than 70% (12 studies with 2074 cases and 3690 controls). Moreover, the susceptibility to gastric carcinogenesis has a substantial influence on the population-attributable risk by modulating the effects of environmental risk factors such as Helicobacter pylori infection (OR = 1.77, 95%CI: 1.05–2.99, P = 0.032). Conclusions :The present meta-analysis results suggest that the LTA rs909253 GA genotype is a possible risk factor for developing gastric cancer in the Asian population, especially those with H. pylori infection. Abbreviations : GC, gastric cancer; LTA, lymphotoxin-
α gene; TNF, tumor necrosis factor; OR, odds ratio; CI, confidence interval; SNPs, single nucleotide polymorphisms; HWE, Hardy-Weinberg equilibrium
Cancer Epidemiology 2012