In vivo diagnosis of melanoma and non-melanoma skin cancer using oblique incidence diffuse reflectance spectrometry
Menée in vivo, cette étude évalue l'intérêt d'une technique de spectroscopie pour faciliter le diagnostic des cancers cutanés
Early detection and treatment of skin cancer can significantly improve patient outcome. However, present standards for diagnosis require biopsy and histopathologic examinations that is relatively invasive, expensive and difficult for patients with many early stage lesions. Here we show an oblique incidence diffuse reflectance spectroscopic (OIDRS) system that can be used for rapid skin cancer detection in vivo. This system was tested under clinical conditions by obtaining spectra from pigmented and non-pigmented skin lesions, including melanomas, differently staged dysplastic nevi and common nevi that were validated by standard patho-histological criteria. For diagnosis of pigmented melanoma, the data obtained achieved 90% sensitivity and specificity for a blinded test set. In a second analysis, we demonstrated that this spectroscopy system can also differentiate non-pigmented basal cell or squamous cell carcinomas from non-cancerous skin abnormalities such as actinic keratoses and seborrheic keratoses, achieving 92% sensitivity and specificity. Taken together, our findings establish how oblique incidence diffuse reflectance spectrometry can be used to more rapidly and easily diagnose skin cancer in an accurate and automated manner in the clinic.
Cancer Research , résumé, 2012