Hepatitis C virus to hepatocellular carcinoma
Cette étude passe en revue les mécanismes par lesquels le virus de l'hépatite C induit un stress oxydant, une résistance à l'insuline, une fibrose, une cirrhose du foie, etc., et joue un rôle dans l'étiologie du carcinome hépatocellulaire
Hepatitis C virus causes acute and chronic hepatitis and can lead to permanent liver damage and hepatocellular carcinoma (HCC) in a significant number of patients via oxidative stress, insulin resistance (IR), fibrosis, liver cirrhosis and HCV induced steatosis. HCV induced steatosis and oxidative stress causes steato-hepatitis and these pathways lead to liver injury or HCC in chronic HCV infection. Steatosis and oxidative stress crosstalk play an important role in liver damage in HCV infection. This Review illustrates viral and host factors which induce Oxidative stress, steatosis and leads toward HCC. It also expresses Molecular cascade which leads oxidative stress and steatosis to HCC.