Chemoprevention of Breast Cancer by Fish Oil in Preclinical Models: Trials and Tribulations
Cet article passe en revue les résultats d'études concernant l'effet chimiopréventif des acides gras oméga 3 sur le risque de cancer du sein, discute les paramètres ayant pu conduire à des résultats controversés et donne des recommandations pour les expérimentations futures
Despite the perception that omega-3 fatty acids (n-3 FA) protect against breast cancer, epidemiologic studies have yielded inconsistent results. Although preclinical data have been, in general, more supportive of a protective effect of n-3 FA on breast cancer, inconsistencies still remain, which preclude definite conclusions or in-depth mechanistic investigations despite 30 years of research in this area. In this review, we discuss key variables that may account for inconsistencies of results across preclinical studies and provide recommendations for future experiments testing the chemopreventive effect of n-3 FAs in breast cancer, as part of a multiagent approach under rigorously controlled conditions.
Cancer Research 2011